from __future__ import print_function # Python 2/3 compatibility import boto3, pprint dynamodb = boto3.resource('dynamodb', region_name='us-west-2') # substitute your preferred region table = dynamodb.Table("Music") # Substitute your table name for RetailDatabase # Delete a region to an existing table. table.update( ReplicaUpdates=[ { 'Delete': { 'RegionName': 'us-east-2', }, } ] )