diff --git a/lib/multihandle.h b/lib/multihandle.h
index a26fb619a..18080f1c3 100644
--- a/lib/multihandle.h
+++ b/lib/multihandle.h
@@ -70,10 +70,6 @@ typedef enum {
 
 #define CURLPIPE_ANY (CURLPIPE_MULTIPLEX)
 
-#if !defined(CURL_DISABLE_SOCKETPAIR)
-#define ENABLE_WAKEUP
-#endif
-
 /* value for MAXIMUM CONCURRENT STREAMS upper limit */
 #define INITIAL_MAX_CONCURRENT_STREAMS ((1U << 31) - 1)